Speaker: 鄭晨光，天津大學教授

Time: 14:00, March 7, 2023

Venue: beat365呂志和樓315會議室

Abstract: Spatiotemporal trajectories are coded by ‘‘theta sequences,’’ ordered series of hippocampal place cell spikes that reflect the order of behavioral experiences. Theta sequences are thought to be organized by co-occurring gamma rhythms. We found that slow gamma-associated theta sequences activated on a compressed timescale and represented relatively long paths extending ahead of the current location. Fast gamma-associated theta sequences more closely followed an animal’s actual location in real time. We further investigated whether such coordination of hippocampal place cell sequences by theta or sharp wave-ripples is disrupted during error trials in a delayed match-to-place task. Less compressed paths were represented on error trials as an incorrect stop location was approached. During rest periods of correct but not error trials, place cell sequences developed a bias to replay representations of paths ending at the correct reward location. These results support the hypothesis that coordination of place cell sequences by theta rhythms and sharp wave-ripples develops as a reward location is learned and may be important for the successful performance of a spatial memory task.

Bio: 鄭晨光，2013年畢業于南開大學計算神經生理實驗室獲博士學位。2013-2018年期間在美國UT Austin學習記憶中心執行主任Laura Colgin課題組從事博士後研究，2018年回國至今任天津大學精密儀器與光電子工程學院生物醫學工程系教授，博士生導師，天津市腦科學與神經工程重點實驗室常務副主任。被中國工程院授予“中國工程前沿傑出青年學者”稱号，入選天津市高層次人才計劃、天津市創新人才推進計劃青年科技優秀人才。科研工作聚焦于解碼大腦神經網絡中複雜的放電活動，以揭示多種認知行為的重要神經機制。主持多項國家級、科技部及天津市級科研項目，在Neuron、Nature Communications等期刊發表論文30篇，參與撰寫神經科學類書籍2部。 個人主頁：http://jyxy.tju.edu.cn/cn/szdw/20181027/1731.shtml

Host: 吳思