姓  名:
邵楓
職  稱:
副教授
研究領域:
心理神經免疫學 拟精神分裂症動物模型的認知障礙及其中樞機制研究
通信地址:
beat365王克桢樓 100080
電子郵件:
shaof@pku.edu.cn

beat365心理學系(現beat365官方网站)副教授,博士

1997 年 9 月 -2000 年 7 月 中國科學院心理研究所(生物心理學) 博士

2000 年 7 月 -2003 年 8 月 beat365心理學系(現beat365官方网站) 講師

2003 年 8 月至今 beat365心理學系(現beat365官方网站) 副教授

科研項目

1、青少期社會隔離誘發大鼠拟精神分裂症認知功能障礙的BDNF表觀遺傳學機制研究,國家自然科學基金會面上項目,80萬,2015.1-2018.12,主持

2、青少年階段社會隔離幹擾中腦多巴胺系統神經發育并誘發成年大鼠認知障礙的分子機制研究, 國家自然科學面上基金, 35萬, 2011.1-2013.12, 主持

3、早期隔離應激誘導的拟精神分裂症颠倒學習障礙的神經生物學機制研究,國家自然科學面上基金,25萬,2007年1-2009年12,主持

4、抑郁症和精神分裂症的基因與環境相互作用機理研究 - 疾病的腦高級功能障礙(子課題), “國家重點基礎研究發展計劃資助(973)”及課題編号2007CB512306, 2007-2012

5、拟精神分裂症動物模型的深入化研究,國家自然科學青年基金,18萬,2002年1-2005年12,主持

6、情緒過程、神經生理機制與教育幹預,教育部科學技術重點項目,1.5萬,2002-2005,參與  

1 ,拟精神分裂症動物模型的認知障礙及其中樞機制研究

2 ,心理神經免疫學研究

英文論著

Xu, H., Wang, JS., Zhang, K., Zhao, M., Ellenbroek, B., Shao,F*., Wang,WW. (2018). Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology, 88,92-101.

Wang, Q., Shao,F*., Wang, WW. (2018). Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress. Neural Plasticity, 2018, 9870985

Sun, L., Min, L., Li, M., Shao,F*., Wang, WW. (2018). Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. Brain Research Bulletin, 142, 304-312

Li, M., Sun, L., Du, W., Zhou, H., Shao,F*., Wang, WW. (2018). Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation. Behavioral Pharmacology, (in press)

Sun, L., Min, L., Zhou, H., Li, M., Shao, F*. (2017). Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behaviroal Brain Research, 333,258-266. (corresponding author)

Zhang, Y., Shao, F., Wang, Q., Xie, X., Wang, W.W. (2017). Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence. Neural Plasticity, 10,1-10.

Tian, Y.L., Yang, CH.J., Shang, SH.J., Cai, Y.J., Deng, X.F., Zhang, J., Shao, F., et al. (2017). Loss of FMRP impaired hippocampal long-term plasticity and spatial learning in rats. Frontiers in Molecular Neuroscience, 10, 1-14

Li, M., Du W., Shao, F*., Wang, W.W. (2016). Cognitive dysfunction and epigenetic laterations of the BDNF gene are reduced by social isolation during early adolescence. Behav Brain Res, 313, 177-183. (corresponding author)

Zhang, F., Yuan, S., Shao, F., & Wang, W. (2016). Adolescent social defeat induced alterations in anxious behavior and cognitive flexibility in adult mice: effects of developmental stage and social condition. Frontiers in Behavioral Neuroscience, 10,149: 1-11.

Xu, H., Zhang, Y., Zhang, F., Yuan, S. N., Shao, F.,& Wang, W. (2016). Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Front Mol Neurosci, 9, 95. doi: 10.3389/fnmol.2016.00095

Wang,Q., Shao, F*., Wang, W.W. (2015). Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in Molecular Neuroscience, 8, 1-8. (corresponding author)

Wu, J.J., Yu, CH.H., Tan, Y., Hou, ZH., Li, M., Shao, F*., Lu, X.X. (2015). Effects of prenatal exposure to silver nanoparticles on spatial cognition and hippocampal neurodevelopment in rats. Environmental Research, 138, 67-73. (corresponding author)

Wang, Q., Li, M., Du, W., Shao, F*., Wang, W.W. (2015). The different effects of maternal separation on spatial learning and reversal learning in rats. Behavioural Brain Research, 280, 16-23. (corresponding author)

Shao, S., Li, M., Du, W., Shao, F*., Wang, W.W. (2014). Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment. Brain Research, 1589, 105-111. (corresponding author)

Luo, X., Yuan, S., Guan,X., Xie, X., Shao, F*., Wang,W. (2014). Juvenile stress affects anxiety-like behavior and limbic monoamines in adult rats. Physilogy and Behavior, 135, 7-16. (corresponding author)

Guan, X., Shao, F., Xie, X., Chen, L., Wang, W. (2014). Effects of aspirin on immobile and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine. Pharmacology Biochemistry and Behavior, 124, 361-366.

Li, M., Xue, X., Shao, S., Shao, F*., & Wang, W. (2013). Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain Research, 1518, 82-90. (corresponding author)

Xue, X., Shao, S., Li, M., Shao, F*., & Wang, W. (2013). Maternal separaton induces alterations of serotonergic system in different aged rats. Brain Research Bulletin, 95, 15-20. (corresponding author)

Shao, F., Han, X., Shao, S., & Wang W. (2013). Adolescent social isolation influcences cognitive function in adult rats. Neural Regeneration Research, 8(11), 1025-1030.

Xue, X., Shao, S., Wang, W., & Shao, F*. (2013). Maternal separation induces alterations in reversal learning and brain-derived neurotrophic factior expression in adult rats. Neuropsychobiology, 68, 243-249.(corresponding author)

Han, X., Li, N., Xue, X., Shao, F*., & Wang, W. (2012). Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain Research, 1447(0), 38-43. (corresponding author)

Han, X., Wang, W., Shao, F*., & Li, N. (2011). Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain Research, 1385, 175-181 (corresponding author)

Han, X., Li, N., Meng, Q., Shao F*., Wang, W (2011). Maternal immune activation impairs reversal learning and increases serum TNF-α in offspring. Neuropsychobiology, 64, 9-14 (corresponding author)

Meng, Q., Li, N., Han, X., Shao, F*., & Wang, W. (2011). Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain. European Journal of Pharmacology,650, 229-232 (corresponding author)

Han, X., Wang, W., Xue X., Shao, F*., & Li, N. (2011). Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats. Brain Research Bulletin,86,173-178 (corresponding author)

Luo,X, Shao, F.,Guan, X., Xie X., Wang, WW. Progress in the “brain-derived neurotrophic factor depression hypothesis”. Neural Regeneration Research, 2010,5(23): 1817-1824

Shao, F., Han, X., Li, N., & Wang, W. (2010). Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats.. European Journal of Pharmacology, 649(1-3), 202-205.

Meng, Q., Li, N., Han, X., Shao, F., & Wang, W. (2010). Peri-adolescence isolation rearing alters social behavior and nociception in rats. Neuroscience Letters, 480(1), 25-29. (corresponding author)

Shao F, Jin J, Meng QX, Liu M, Xie X, Lin WJ, Wang WW (2009). Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats. Physiol Behav, 98: 251-257

Jihuan Chen, Wenjuan Lin, Weiwen Wang, Feng Shao (2004). Enhancement of antibody production and expression of c-fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm. Behavioural Brain Research, 154: 557-565

Shao Feng, Lin Wenjuan, Wang Weiwen. (2003). The effect of emotional stress on the primary humoral immunity of rats. J of psychopharmacology, 17(2):153-157

Li Liang Shao Feng (2003). Impaired auditory sensorimotor gating: An animal model of schizophrenia. Chinese Science Bulletin, 48(19):2031-2037

Lin Wenjuan Wang Weiwen Shao Feng (2003). New animal model of emotional stress: Behavioral, neuroendocrien and immunological consequences. Chinese Science Bulletin, 48(15): 1565-1568

中文論著

王瓊,王玮文,李曼,杜偉,邵楓*. 阻斷内側前額葉皮質TrkB受體對大鼠認知和海馬BDNF表達的影響. 心理學報, 2016, 48(5), 509-517. ( 通訊作者)

原三娜,羅曉敏,張帆,邵楓,王玮文. 大鼠注意定勢轉移任務模型的深入研究:種系和檢測程序的影響. 心理學報, 2014, 46, 1-9.

張帆, 雍武,邵楓,王玮文.中樞肥大細胞在腦功能和行為調節中的作用. 心理科學進展,2014, 22, 1-11.

薛曉芳,李曼,王玮文,邵楓.母嬰分離的動物模型及其神經生物學機制.心理科學進展,2013,21(6):990-998.(通訊作者)

謝希, 邵楓, 羅曉敏, 管西婷, 孟慶軒, 王玮文.氟西汀和丙米嗪對應激誘導的青幼期大鼠抑郁和焦慮樣行為的不同影響.中國神經精神疾病雜志,2010,36(1):14-18

金暕,王玮文,孟慶軒,劉美,邵楓.不同發育階段社會隔離對成年大鼠潛伏抑制的影響.beat365學報(自然科學版), 2009,45(2):350-354

金暕,王玮文,劉美,邵楓. 精神分裂症社會隔離動物模型的研究進展. 中華行為醫學與腦科學雜志,2009,18(6): 568-570

王玮文 邵楓 劉美 金簡 林文娟.慢性應激損害大鼠信号逆反學習能力:一種新的T型水迷宮檢測方法.中國神經精神疾病雜志, 2009, 15(1): 42-44

邵楓,王玮文,劉美, 金暕. 精神分裂症的潛伏抑制動物模型. 心理科學進展, 2008,16(3):392-398

邵楓,李量,王玮文. 阿撲嗎啡注射對大鼠視覺線索辨别學習和逆反學習的影響. 中國行為醫學科學, 2008, 17(3): 193-195

劉美, 王玮文, 金暕,邵楓. 青春期阿撲嗎啡注射對大鼠潛伏抑制和高架十字迷宮行為的影響. 中國行為醫學科學, 2008, 17(3): 196-198

王玮文,謝希,邵楓. 早發性抑郁及其神經基礎. 心理科學進展, 2008,16(3):411-417

劉美,王玮文,邵楓. 不同種系大鼠潛伏抑制模型的建立與評價. 中國行為醫學科學,2007,16(7): 577-579

王玮文,邵楓,林文娟. 不同時程應激對大鼠行為、免疫和交感神經系統反應的影響.心理學報,2007, 39(2): 292-298

王玮文,邵楓,劉美,孫萌,林文娟. 慢性應激對大鼠行為和免疫細胞熱休克蛋白70表達的影響. 心理學報, 2007, 39(5): 500-510

王玮文, 邵楓, 劉美, 林文娟. 老化,慢性應激與免疫細胞熱休克蛋白70反應抑制. 中國行為醫學科學, 2007,16(10):951-953

王玮文,邵楓,劉美,林文娟. 早期應激對抑郁相關行為及神經内分泌反應的長期影響. 心理科學進展,2006,14(6):907-911

何淑嫦,牛僑,邵楓,王生.鋁染毒對元代培養神經細胞線粒體氧化功能的損傷. 衛生研究, 2005 (6):685-687

何淑嫦,邵楓,牛僑. 鋁染毒大鼠學習記憶和氨基酸類神經遞質的改變.中國行為醫學科學 2005(1):11-12

邵楓 李量 耿曉峰. 一次阿撲嗎啡注射對大鼠視覺辨别學習和工作記憶的影響. 中國行為醫學科學,2004,13(1):5-7

邵楓 李量 耿曉峰. 早期應激與精神分裂症. 中國行為醫學科學,2004,13(2):228-229

邵楓 何淑嫦 耿曉峰. 早期隔離應激對大鼠視覺線索辨别學習和逆反學習的影響. 中國行為醫學科學,2004,13(3):247-248

邵楓 林文娟 肖健. 交感神經系統在應激免疫調節中的作用. 心理學報, 2003, 35(4):559-562

邵楓 林文娟. 情緒應激免疫調節作用的中樞機制研究. 心理學報, 2003,35(5):685-689

邵楓 林文娟 陳極寰. 慢性情緒應激對大鼠行為的影響及變化趨勢. 中國行為醫學科學, 2003, 12(1): 5-7

邵楓 林文娟. 電擊信号應激免疫調節作用的中樞機制研究. 中國行為醫學科學, 2003, 12(2):137-139

李量 邵楓. 精神分裂症的感覺運動門控障礙的動物模型. 科學通報中文, 2003, 48(15):1603-1612

林文娟 王玮雯 邵楓. 慢性情緒應激對大鼠行為神經内分泌和免疫反應的影響-一個新的情緒應激模型. 科學通報中文, 2003, 48(9):926-929

邵楓,林文娟. 情緒應激體液免疫調節作用的影響因素研究,心理學報,2001,33(6):543-547

邵楓,林文娟,王玮雯. 心理應激的免疫抑制作用及其與神經内分泌反應的相關性研究, 心理學報,2001,33(1):43-47

邵楓,林文娟,王玮雯,鄭麗. 電擊信号應激對大鼠體液免疫及内分泌功能的影響,心理學報,2000,32(4):428-432

邵楓,林文娟. 外周交感神經系統在情緒應激體液免疫調節中的作用,中國行為醫學科學,2001,10(5):401-404

邵楓, 林文娟, 王玮雯. 情緒應激對大鼠體液免疫功能的影響及有關機制研究, 基礎醫學與臨床, 2002年1月 第22卷(增刊) 41頁

邵楓, 王玮雯,林文娟. 兩種情緒應激模式免疫調節腦機制的比較研究,基礎醫學與臨床, 2002年1月 第22卷(增刊) 45頁

鄭麗,林文娟,邵楓. 對體液免疫反應的條件反射性調節,心理科學,2002,25(1):27-30

陳極寰,林文娟,邵楓. 條件反射性抗體反應增強的動态分析-以OVA為非條件刺激物,心理學報, 2003, 35(2):261-265

邵楓,林文娟,王玮雯,鄭麗. 電擊信号應激對大鼠體液免疫及内分泌功能的影響,心理學報,2000,32(4):428-432