姓　　名：
謝夢
職　　稱：
助理研究員
研究領域：
代謝生物學 發育生物學
通信地址：
beat365呂志和樓329
電子郵件：
meng.xie@pku.edu.cn

謝夢博士于2007年畢業于英國曼徹斯特大學生命科學系（University of Manchester，Department of Life Science）獲得藥理學學士學位。期間在英國柴郡阿斯利康制藥公司（AstraZeneca, Cheshire, UK）全職實習一年(2005-2006)。

2008年畢業于英國曼徹斯特大學生命科學系（University of Manchester，Department of Life Science），獲得分子生物學碩士學位。

2014年畢業于加拿大麥吉爾大學生物系（McGill University, Department of Biology），獲得生物學博士學位。

2015至2020年，于瑞典卡羅林斯卡醫學院從事博士後研究工作。

2020年12月起任任beat365官方网站助理研究員、IDG麥戈文腦科學研究所Co-PI（Carlos Ibanez教授課題組）。

主持科研項目：

1. 瑞典卡羅林斯卡醫學院, Ulla and Gustaf af Uggla Foundation on arthropathic diseases，2019-01799, Cellular Dynamics behind Formation of Synovial Joints, 2019-01至2019-12

2. 瑞典卡羅林斯卡醫學院, Foundation for Rheumatology Research from Karolinska Institutet, 2018-02782, Characterization of newly discovered chondrocyte progenitors and their potential to heal damaged articular cartilage, 2019-01至2019-12

3. 斯德哥爾摩共濟會兒童之家基金會, Stiftelsen Frimurare Barnhuset I Stockholm Foundation, Characterization of a feedback loop from the growth plate to the GH/IGF1 system, 2019-04至2019-12

4. 瑞典卡羅林斯卡醫學院，Alex and Eva Foundation from Karolinska Institutet，2017-00433，Characterization of newly discovered chondrocyte progenitors and their potential to heal damaged articular cartilage, 2017-01至2017-12

5. 瑞典卡羅林斯卡醫學院，Loo and Han Osterman Foundation from Karolinska Institutet，2017-00116, Exploring regenerative potential of articular cartilage in relation to osteoarthritis, 2017-03至2018-02

6. 歐洲分子生物學協會 (European Molecular Biology Organization (EMBO))，EMBO Long-Term Fellowship, ALTF 2014-1296, Characterization of a feedback loop from the growth plate to the GH/IGF1 system, 2015-04至2017-03

參加科研項目：

1. 瑞典卡羅林斯卡醫學院, SFO Stem cells and Regenerative medicine, 2018 Junior grant, A novel stem cell niche in the epiphyseal growth plate, 2018-2020,

2. 瑞典研究理事會(Swedish Research Council), Research grant, 2016-02835, Exploring regenerative potential of articular cartilage in relation to osteoarthritis, 2017-2020

謝夢博士專長于代謝生物學和發育生物學。主要研究興趣集中于：

1. 環境和遺傳條件對于脂肪組織多樣性和可塑性的影響

2. 胚胎時期脊柱發育背後的細胞動力學和分子調控機制

3. 膝關節各組成部分之間在細胞和分子層面的區别與聯系

Xie M, Gol'din P, Herdina AN, Estefa J, Medvedeva EV, Li L, Newton PT, Kotova S, Shavkuta B, Saxena A, Shumate LT, Metscher BD, Großschmidt K, Nishimori S, Akovantseva A, Usanova AP, Kurenkova AD, Kumar A, Arregui IL, Tafforeau P, Fried K, Carlström M, Simon A, Gasser C, Kronenberg HM, Bastepe M, Cooper KL, Timashev P, Sanchez S, Adameyko I, Eriksson A, Chagin AS. Secondary ossification center induces and protects growth plate structure. Elife. 2020 Oct 16;9:e55212. doi: 10.7554/eLife.55212.

Xie M, Chagin AS. The epiphyseal secondary ossification center: Evolution, development and function. Bone. 2020 Oct 19:115701. doi: 10.1016/j.bone.2020.115701.

Zhang Y, Annusver K, Sunadome K, Kameneva K, Edwards S, Kasper M, Chagin AS, Adameyko I*, Xie M*. Epiphyseal cartilage formation involves differential dynamics of various cellular populations during embryogenesis. Frontiers in Cell and Developmental Biology. 2020 Mar 5;8:122. doi: 10.3389/fcell.2020.00122. eCollection 2020. *Corresponding authors

Zhang Y, Kameneva P, Annusver K, Kasper M, Chagin AS, Adameyko I*, Xie M*. Cruciate ligament, patellar tendon and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds. Developmental Dynamics. 2020 Jun;249(6):711-722. doi: 10.1002/dvdy.158. * Corresponding authors

Xie M, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, Storer M, Fried K, Adameyko I, Dyachuk V, Chagin AS. Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15068-15073. doi: 10.1073/pnas.1900038116.

Xie M, Li JP. Heparan sulfate proteoglycan - A common receptor for diverse cytokines. Cell Signal. 2019 Feb;54:115-121. doi: 10.1016/j.cellsig.2018.11.022.

Xie M and Roy R. AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae. PLoS One. 2015 Jun 22;10(6):e0130480. doi: 10.1371/journal.pone.0130480.

Xie M and Roy R. The Causative Gene in Chanarian-Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. PLoS Genetics. 2015 Jun 17;11(6):e1005284. doi: 10.1371/journal.pgen.1005284.

Xie M and Roy R. Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Remodelling of Lipid Metabolism in C. elegans. Cell Metabolism. 2012 Sep 5;16(3):322-35.

Xie M, Alonso H and Roujeinikova A. An Improved Procedure for the Purification of Catalytically Active Alkane Hydroxylase from Pseudomonas putida GPo1. Appl Biochem Biotechnol. 2011 Oct;165(3-4):823-3.

Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, Sävendahl L, Chagin AS. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature. 2019 Mar;567(7747):234-238. doi: 10.1038/s41586-019-0989-6.

Newton PT, Xie M, Medvedeva EV, Sävendahl L, Chagin AS. Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered. Bone Rep. 2018 Feb 24;8:64-71. doi: 10.1016/j.bonr.2018.02.006.

Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME, Xie M, Kicheva A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser M, Chagin AS, Fried K, Adameyko I. Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. Elife. 2018 Jun 13;7. pii: e34465. doi: 10.7554/eLife.34465.

Li L, Newton PT, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, Xie M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar AB, Warman ML, Barenius B, Adameyko I, Chagin AS. Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice. FASEB Journal 2017 Mar;31(3):1067-1084. doi: 10.1096/fj.201600918R.

Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J, Xie M, Petersen J, Pachnis V, Nicolis SK, Yu T, Sharpe P, Arenas E, Brismar H, Blom H, Clevers H, Suter U, Chagin AS, Fried K, Hellander A, Adameyko I. Analysis of neural crest-derived clones reveals novel aspects of facial development. Science Advances 2016 Aug 3;2(8):e1600060. doi: 10.1126/sciadv.1600060.

Andrew D, Xie M, Bottomley S, Wilce M and Roujeinikova A. Design, purification and characterization of the soluble variant of the integral membrane protein MotB for structural studies. J. R. Soc. Interface. 2013 Feb 6;10(79):20120717.

O’Neil J, Xie M, Hijnen M and Roujeinikova. Role of the MotB linker in the assembly and activation of the bacterial flagellar motor. Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1009-16.